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Volume 35 , Issue 3
May/June 2015
Pages 325-333

Tissue Engineering for Lateral Ridge Augmentation with Recombinant Human Bone Morphogenetic Protein 2 Combination Therapy: A Case Report

George A. Mandelaris, DDS, MS/Daniel B. Spagnoli, DDS, MS, PhD/Alan L. Rosenfeld, DDS/James McKee, DDS/Mei Lu, DDS, MSD, PhD

PMID: 25909520
DOI: 10.11607/prd.2378

This case report describes a tissue-engineered reconstruction with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ ACS) + cancellous allograft and space maintenance via Medpor Contain mesh in the treatment of a patient requiring maxillary and mandibular horizontal ridge augmentation to enable implant placement. The patient underwent a previously unsuccessful corticocancellous bone graft at these sites. Multiple and contiguous sites in the maxilla and in the mandibular anterior, demonstrating advanced lateral ridge deficiencies, were managed using a tissue engineering approach as an alternative to autogenous bone harvesting. Four maxillary and three mandibular implants were placed 9 and 10 months, respectively, after tissue engineering reconstruction, and all were functioning successfully after 24 months of follow-up. Histomorphometric analysis of a bone core obtained at the time of the maxillary implant placement demonstrated a mean of 76.1% new vital bone formation, 22.2% marrow/cells, and 1.7% residual graft tissue. Tissue engineering for lateral ridge augmentation with combination therapy requires further research to determine predictability and limitations.

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